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Was this page helpful? Your Pain. In anal sex addicts and marrage trouble way, the induction of CDK5 gene expression occurs together with suppression of the G9A gene coding for dimethyltransferase acting on the histone H3. This is reflected in the increased, stable and long-lasting level of sensitivity to cocaine and other drugs, and tendency to relapse even after long periods of abstinence. It is ironic and unfortunate that the Manual avoids use of the term addiction, which provides the best description of the clinical syndrome. The practice of emotionally focused couples therapy: Creating connection.